Monday, June 4, 2018

7-azaindoles & 2-amino-6-methylpyridine Description & Chemical Properties

Azaindole platform is a standout amongst the most advantaged structures as a bioisostere
for indoles with a wide variety of nuclear activities and has been found in an expansive
number of pharmaceutical molecules and medication competitors. Because of its remarkable
capacity to act as both donor and acceptor of hydrogen bonds, 7-azaindole have been known
to show different natural profiles, for example, anti-tumor, anti-bacterial, and calming exercises.
With the development of synergist C-H bond functionalization, C-N bond formation responses
have been of incredible enthusiasm for natural and therapeutic chemistry due to the
pervasiveness of bioactive N-containing heterocycles.

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We thus report the Rh(III)- catalyzed coordinate amination of 7-azaindole with anthranilic bearing ortho-aminated azaindole derivatives as organically fascinating
heterocycles. Besides, synthetic mixes were tried against different cancer cell lines, for
example, human breast adenocarcinoma cells (MCF-7), human renal carcinoma cells
(786-O), and human prostate adenocarcinoma cells (DU145). Curiously, you might have
watched promising anticancer properties of 7-azaindole containing the 2-formyl aniline
moiety, which was competitive with anticancer doxorubicin as a positive control.

  • 7-Azaindole, 98%
  • MDL MFCD00005606 EINECS 205-981-0

Chemical Properties:

  • Formula: C7H6N2
  • Formula Weight: 118.14
  • Melting point: 103-107°
  • Boiling Point: 270°Synthesis and pharmacological activities of 7-azaindole derivatives.

As a piece of the program to find novel analogs of 7-azaindole (1H-Pyrrolo[2,3-b] pyridine)
having critical biological exercises, a few derivatives have been integrated and assessed
for their pain analgesic and hypotensive movement. Compounds evaluated by warm stimuli
(tail submersion strategy) at the dose of 50 mg/kg of body weight uncovered critical pain
analgesic activity. Pethidine was utilized as reference drug. Same compounds tested at
the dose of 75 mg/kg of body weight showed harmfulness. Compounds tested for their
impact on the pulse in normotensive rat produced slight fall in blood pressure.


In the asymmetric unit test, C6H9N2+·C7H7O3S−, there are two free
2-Amino-6-methylpyridine cations and two autonomous 4-methyl­benzene­sulfonate
anions. The two cations are protonated at their pyridine N atoms, and their geometries
reveal amine– imine tautomerism. In the 4-methyl­benzene­sulfonate anions, the
carboxyl­ate groups are taken out of the benzene ring. The sulfonate O atoms of an
anion inter­act with the protonated N atoms and the 2-amino group of a cation via
N—H⋯O hydrogen bonds, forming an R22(8) ring theme. These motifs are associated
via N—H⋯O hydrogen bonds, forming chains running along the a-axis direction. Inside
the chains, there are frail C—H⋯O hydrogen bonds present.

Here are some of the chemical properties of 2-Amino-6-methylpyridine.

  • CID: 15765
  • Chemical Names: 2-Amino-6-methylpyridine; 1824-81-3; 2-Amino-6-picoline; 6-methylpyridin-2-amine; 6-Amino-2-picoline; 2-Pyridinamine, 6-methyl-   More...
  • Molecular Formula: C6H8N2
  • Molecular Weight: 108.144 g/mol
  • Substance Registry: FDA UNII
  • Safety Summary: Laboratory Chemical Safety Summary (LCSS)

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